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GPCR

NameCysteinyl leukotriene receptor 1
SpeciesHomo sapiens (Human)
GeneCYSLTR1
SynonymLTD4 receptor
LTD4
leukotriene D4 receptor
HMTMF81
HG55
[ Show all ]
DiseaseN/A
Length337
Amino acid sequenceMDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
UniProtQ9Y271
Protein Data BankN/A
GPCR-HGmod modelQ9Y271
3D structure modelThis predicted structure model is from GPCR-EXP Q9Y271.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1798
IUPHAR269
DrugBankBE0000705

Ligand

NamePranlukast
Molecular formulaC27H23N5O4
IUPAC nameN-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide
Molecular weight481.512
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP4.2
SynonymsP2115
177P373
SCHEMBL18058592
AB2000316
Tox21_112952
[ Show all ]
Inchi KeyNBQKINXMPLXUET-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32)
PubChem CID4887
ChEMBLCHEMBL21333
IUPHAR3634
BindingDB50023198
DrugBankDB01411

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank
IC500.1 nMPMID10462554IUPHAR
IC500.8 nMPMID20621485BindingDB,ChEMBL
IC504.3 nMPMID26200813BindingDB,ChEMBL
IC504.3 - 7.2 nMPMID10391245, PMID10462554IUPHAR
IC5023.0 nMPMID26985325BindingDB
Ki1.58489 - 79.4328 nMPMID11996896, PMID9504401IUPHAR

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