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GPCR

Name	Uracil nucleotide/cysteinyl leukotriene receptor
Species	Homo sapiens (Human)
Gene	GPR17
Synonym	GPR17 P2Y-like receptor G-protein coupled receptor 17 R12 UDP/CysLT receptor uracil nucleotide/cysteinyl leukotriene receptor [ Show all ]
Disease	N/A
Length	367
Amino acid sequence	MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
UniProt	Q13304
Protein Data Bank	N/A
GPCR-HGmod model	Q13304
3D structure model	This predicted structure model is from GPCR-EXP Q13304.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075162
IUPHAR	88
DrugBank	N/A

Ligand

Name	Pranlukast
Molecular formula	C27H23N5O4
IUPAC name	N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide
Molecular weight	481.512
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	4.2
Synonyms	DSSTox_CID_23782 HMS3650A14 MFCD24539454 N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenyl-butoxy)-benzamide O046 pranlukast hydrate SR-05000001474 AK481332 BCP04577 BRD-K97045029-001-04-3 CTK7F7297 DTXSID3043782 K-0349 MolPort-035-394-920 N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenylbutoxy)benzamide Ono-RS-411 103177-37-3 (anhyd.) SB19080 8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5-yl)-4-oxo-4H-1-benzopyran SR-05000001474-3 API0009100 CCN 00401 GTPL3634 LS-194954 N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide NBQKINXMPLXUET-UHFFFAOYSA-N SCHEMBL3693 AC-696 UNII-TB8Z891092 Azlaire (TN) CHEMBL21333 DSSTox_GSID_43782 HMS3714E03 MLS006010078 N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenyl-butoxy)-benzamide (ONO-RS-411) ONO RS-411 Pranlukast [INN:BAN] 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran SR-05000001474-1 AKOS015967342 BDBM50023198 CAS-103177-37-3 D08408 FT-0652673 KS-00000YQJ N-(4-OXO-2-(1H-TETRAZOL-5-YL)-4H-CHROMEN-8-YL)-4-(4-PHENYLBUTOXY)BENZAMIDE N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide Onon 150821-03-7 SC-15917 AB01275471-01 TB8Z891092 AS-15105 CHEBI:94810 DB01411 HMS2089H16 LS-194966 N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-P-(4-phenylbutoxy)benzamide;N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-P-(4-phenylbutoxy)benzamide NCGC00181765-01 Pranlukast (INN) 4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran SMR004701229 AC1L1J6B ZINC1542146 BC220515 BRD-K97045029-001-01-9 CS-2304 DSSTox_RID_80074 HY-B0290 MolPort-003-849-959 N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenyl-butoxy)-benzamide(ONO-RS-411) Ono-1078 103177-37-3 SB-205312 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran;8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran SR-05000001474-2 AN-15615 CCG-220661 D08QIP GP8160 L013134 N-(4-oxo-2-(2H-tetrazol-5-yl)-4H-chromen-8-yl)-4-(4-phenylbutoxy)benzamide N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide P2115 177P373 SCHEMBL18058592 AB2000316 Tox21_112952 Azlaire [ Show all ]
Inchi Key	NBQKINXMPLXUET-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32)
PubChem CID	4887
ChEMBL	CHEMBL21333
IUPHAR	3634
BindingDB	50023198
DrugBank	DB01411
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4060.0 nM	PMID24900835	BindingDB,ChEMBL

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