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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL367418
Molecular formulaC30H30FN5O2
IUPAC name4-(4-fluorophenyl)-N,N-dimethyl-3-[6-(2-methylimidazo[4,5-c]pyridin-1-yl)hexanoyl]indole-1-carboxamide
Molecular weight511.601
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.8
SynonymsBDBM50062052
N,N-Dimethyl-3-[6-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)hexanoyl]-4-(4-fluorophenyl)-1H-indole-1-carboxamide
4-(4-Fluoro-phenyl)-3-[6-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-hexanoyl]-indole-1-carboxylic acid dimethylamide
Inchi KeyBEWNCONODDVMMY-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H30FN5O2/c1-20-33-25-18-32-16-15-26(25)35(20)17-6-4-5-10-28(37)24-19-36(30(38)34(2)3)27-9-7-8-23(29(24)27)21-11-13-22(31)14-12-21/h7-9,11-16,18-19H,4-6,10,17H2,1-3H3
PubChem CID11799893
ChEMBLCHEMBL367418
IUPHARN/A
BindingDB50062052
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki3.2 nMPMID9438024BindingDB,ChEMBL

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