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Name | Neuromedin-K receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Tacr3 |
Synonym | Tac3r SP-N receptor Nmkr NKR NK3 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 452 |
Amino acid sequence | MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS |
UniProt | P16177 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3154 |
IUPHAR | 362 |
DrugBank | N/A |
Name | CHEMBL406812 |
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Molecular formula | C65H100N18O13S |
IUPAC name | (2S)-2-[[(2R)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(1S)-2-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-(2,3-dihydro-1H-inden-2-yl)-2-oxoethyl]amino]-1,5-dioxopentan-2-yl]pentanediamide |
Molecular weight | 1373.69 |
Hydrogen bond acceptor | 17 |
Hydrogen bond donor | 15 |
XlogP | -2.0 |
Synonyms | Arg-Pro-Lys-Pro-Gln-Gln-2Ing-Phe-Gly-Leu-Met BDBM50030147 |
Inchi Key | NCXMVPIEFNEZND-FFRQMEGJSA-N |
Inchi ID | InChI=1S/C65H100N18O13S/c1-37(2)32-47(59(91)76-43(55(70)87)26-31-97-3)75-53(86)36-74-56(88)48(33-38-14-5-4-6-15-38)80-62(94)54(41-34-39-16-7-8-17-40(39)35-41)81-58(90)45(23-25-52(69)85)77-57(89)44(22-24-51(68)84)78-60(92)50-21-13-30-83(50)64(96)46(19-9-10-27-66)79-61(93)49-20-12-29-82(49)63(95)42(67)18-11-28-73-65(71)72/h4-8,14-17,37,41-50,54H,9-13,18-36,66-67H2,1-3H3,(H2,68,84)(H2,69,85)(H2,70,87)(H,74,88)(H,75,86)(H,76,91)(H,77,89)(H,78,92)(H,79,93)(H,80,94)(H,81,90)(H4,71,72,73)/t42-,43-,44-,45-,46-,47-,48-,49-,50+,54-/m0/s1 |
PubChem CID | 44287932 |
ChEMBL | CHEMBL406812 |
IUPHAR | N/A |
BindingDB | 50030147 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <10000.0 nM | PMID7515443 | BindingDB,ChEMBL |
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