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Name | Alpha-2C adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA2C |
Synonym | alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I [ Show all ] |
Disease | Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease [ Show all ] |
Length | 462 |
Amino acid sequence | MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ |
UniProt | P18825 |
Protein Data Bank | N/A |
GPCR-HGmod model | P18825 |
3D structure model | This predicted structure model is from GPCR-EXP P18825. |
BioLiP | N/A |
Therapeutic Target Database | T01777 |
ChEMBL | CHEMBL1916 |
IUPHAR | 27 |
DrugBank | BE0004864, BE0000342, BE0004888 |
Name | AGN 192836 |
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Molecular formula | C12H13N3O2 |
IUPAC name | N-(5-methyl-2,3-dihydro-1,4-benzodioxin-6-yl)-1H-imidazol-2-amine |
Molecular weight | 231.255 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 2.0 |
Synonyms | BDBM50055832 171102-29-7 CS-0018452 2-[[(5-Methyl-2,3-dihydro-1,4-benzodioxin)-6-yl]amino]-1H-imidazole HY-100300 [ Show all ] |
Inchi Key | NDFYRGCPDAFQDG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H13N3O2/c1-8-9(15-12-13-4-5-14-12)2-3-10-11(8)17-7-6-16-10/h2-5H,6-7H2,1H3,(H2,13,14,15) |
PubChem CID | 10176999 |
ChEMBL | CHEMBL308570 |
IUPHAR | N/A |
BindingDB | 50055832 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 6.6 nM | PMID9016324 | BindingDB,ChEMBL |
IA | 0.5 - | PMID9016324 | ChEMBL |
Ki | 19.0 nM | PMID9016324 | BindingDB,ChEMBL |
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