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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Mus musculus (Mouse)
Gene	Chrm3
Synonym	cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 cholinergic receptor M3 receptor M3R Mm3 mAChR HM4 [ Show all ]
Disease	N/A for non-human GPCRs
Length	589
Amino acid sequence	MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
UniProt	Q9ERZ3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	158930-48-4
Molecular formula	C7H12N2O2
IUPAC name	methyl 6-amino-2,3,4,5-tetrahydropyridine-3-carboxylate
Molecular weight	156.185
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	-1.0
Synonyms	6-Amino-2,3,4,5-tetrahydro-pyridine-3-carboxylic acid methyl ester; hydrochloride SCHEMBL8309304 CHEMBL1194965 L008011 AKOS027399303 3-pyridinecarboxylic acid,6-amino-2,3,4,5-tetrahydro-,methyl ester CHEMBL553602 6-Amino-2,3,4,5-tetrahydro-3-pyridinecarboxylic acid methyl ester Methyl 6-amino-2,3,4,5-tetrahydropyridine-3-carboxylate 158832-45-2 BDBM50039848 3-Pyridinecarboxylicacid,6-amino-2,3,4,5-tetrahydro-,methylester(9CI) KB-184721 [ Show all ]
Inchi Key	NDYOGNUJWRYXIH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H12N2O2/c1-11-7(10)5-2-3-6(8)9-4-5/h5H,2-4H2,1H3,(H2,8,9)
PubChem CID	10012139
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50039848
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14000.0 nM	PMID9111297	BindingDB

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