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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Rattus norvegicus (Rat)
Gene	Glp1r
Synonym	GLP-1 receptor GLP-1-R GLP-1R glucagon-like peptide 1 receptor
Disease	N/A for non-human GPCRs
Length	463
Amino acid sequence	MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
UniProt	P32301
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5862
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL510593
Molecular formula	C56H52N4O14S2
IUPAC name	1,3-bis[[4-(cyclopentanecarbonylamino)benzoyl]amino]-2,4-bis[3-methoxy-4-(thiophene-2-carbonyloxy)phenyl]cyclobutane-1,3-dicarboxylic acid
Molecular weight	1069.17
Hydrogen bond acceptor	16
Hydrogen bond donor	6
XlogP	8.6
Synonyms	CHEMBL2158418 SCHEMBL12216455 1,3-bis(4-(cyclopentanecarboxamido)benzamido)-2,4-bis(3-methoxy-4-(thiophene-2-carbonyloxy)phenyl)cyclobutane-1,3-dicarboxylic acid BDBM50260245 2,4-Bis[4-[(2-thienyl)carbonyloxy]-3-methoxyphenyl]-1,3-bis[[4-[(cyclopentylcarbonyl)amino]benzoyl]amino]cyclobutane-1,3-dicarboxylic acid
Inchi Key	NEGLAHVNMIDVPL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C56H52N4O14S2/c1-71-41-29-35(19-25-39(41)73-51(65)43-13-7-27-75-43)45-55(53(67)68,59-49(63)33-15-21-37(22-16-33)57-47(61)31-9-3-4-10-31)46(36-20-26-40(42(30-36)72-2)74-52(66)44-14-8-28-76-44)56(45,54(69)70)60-50(64)34-17-23-38(24-18-34)58-48(62)32-11-5-6-12-32/h7-8,13-32,45-46H,3-6,9-12H2,1-2H3,(H,57,61)(H,58,62)(H,59,63)(H,60,64)(H,67,68)(H,69,70)
PubChem CID	24994287
ChEMBL	CHEMBL510593
IUPHAR	N/A
BindingDB	50260245
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	37.0 %	PMID17213311	ChEMBL
EC50	657.0 nM	PMID22103243	BindingDB
EC50	1080.0 nM	PMID17213311	BindingDB,ChEMBL
IC50	300.0 nM	PMID22103243	BindingDB
Ki	287.0 nM	PMID17213311	BindingDB,ChEMBL

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