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GPCR

NameN-formyl peptide receptor 3
SpeciesHomo sapiens (Human)
GeneFPR3
SynonymFMLP-related receptor II
Lxa4r
LXA4-R
FPRL2
Fprl1
[ Show all ]
DiseaseN/A
Length353
Amino acid sequenceMETNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMTRTVNTICYLNLALADFSFSAILPFRMVSVAMREKWPFGSFLCKLVHVMIDINLFVSVYLITIIALDRCICVLHPAWAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISTTNGDTYCIFNFAFWGDTAVERLNVFITMAKVFLILHFIIGFSVPMSIITVCYGIIAAKIHRNHMIKSSRPLRVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGKYKIILVLINPTSSLAFFNSCLNPILYVFMGRNFQERLIRSLPTSLERALTEVPDSAQTSNTDTTSASPPEETELQAM
UniProtP25089
Protein Data BankN/A
GPCR-HGmod modelP25089
3D structure modelThis predicted structure model is from GPCR-EXP P25089.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR224
DrugBankN/A

Ligand

NameCHEMBL2391265
Molecular formulaC28H25N3O6
IUPAC nameN-(1,3-benzodioxol-5-yl)-2-[3-(4-methoxyphenyl)-5-[(3-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]acetamide
Molecular weight499.523
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP4.0
SynonymsBDBM50435927
Inchi KeyNELZWWAIOGCPRE-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H25N3O6/c1-34-22-9-6-19(7-10-22)24-14-20(12-18-4-3-5-23(13-18)35-2)28(33)31(30-24)16-27(32)29-21-8-11-25-26(15-21)37-17-36-25/h3-11,13-15H,12,16-17H2,1-2H3,(H,29,32)
PubChem CID71698709
ChEMBLCHEMBL2391265
IUPHARN/A
BindingDB50435927
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<50000.0 nMPMID23685570BindingDB

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