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Name | Muscarinic acetylcholine receptor M1 |
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Species | Mus musculus (Mouse) |
Gene | Chrm1 |
Synonym | cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 460 |
Amino acid sequence | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC |
UniProt | P12657 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3733 |
IUPHAR | 13 |
DrugBank | N/A |
Name | BRN 5829247 |
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Molecular formula | C16H20FN3O3S |
IUPAC name | N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-4-fluoro-2-nitroaniline |
Molecular weight | 353.412 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 3.5 |
Synonyms | DTXSID80162155 BDBM50004673 N-[2-[[5-(dimethylaminomethyl)furan-2-yl]methylsulfanyl]ethyl]-4-fluoro-2-nitroaniline 2-Furanmethanamine,5-[[[2-[(4-fluoro-2-nitrophenyl)amino]ethyl]thio]methyl]-N,N-dimethyl- CHEMBL104355 [ Show all ] |
Inchi Key | NEZXWTGSAGKVIL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H20FN3O3S/c1-19(2)10-13-4-5-14(23-13)11-24-8-7-18-15-6-3-12(17)9-16(15)20(21)22/h3-6,9,18H,7-8,10-11H2,1-2H3 |
PubChem CID | 3072503 |
ChEMBL | CHEMBL104355 |
IUPHAR | N/A |
BindingDB | 50004673 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 4000.0 nM | PMID1507203 | BindingDB,ChEMBL |
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