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GLASS

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GPCR

Name	Follicle-stimulating hormone receptor
Species	Homo sapiens (Human)
Gene	FSHR
Synonym	Follitropin receptor FSH receptor FSH-R LGR1
Disease	Female infertility African trypanosomiasis Contraception Ovarian cancer
Length	695
Amino acid sequence	MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
UniProt	P23945
Protein Data Bank	4mqw
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mqw.
BioLiP	BL0274372
Therapeutic Target Database	T68334
ChEMBL	CHEMBL2024
IUPHAR	N/A
DrugBank	BE0000387

Ligand

Name	CHEMBL3263686
Molecular formula	C30H36N4O3
IUPAC name	N-[5-(2-cyclopentylethylcarbamoyl)-2-[4-(2-methylphenyl)piperazin-1-yl]phenyl]furan-2-carboxamide
Molecular weight	500.643
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	6.1
Synonyms	BDBM50012115 SCHEMBL14651722
Inchi Key	NFLIDPIJHVWPBG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H36N4O3/c1-22-7-2-5-10-26(22)33-16-18-34(19-17-33)27-13-12-24(29(35)31-15-14-23-8-3-4-9-23)21-25(27)32-30(36)28-11-6-20-37-28/h2,5-7,10-13,20-21,23H,3-4,8-9,14-19H2,1H3,(H,31,35)(H,32,36)
PubChem CID	71234066
ChEMBL	CHEMBL3263686
IUPHAR	N/A
BindingDB	50012115
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	129000.0 nM	PMID24685543	BindingDB,ChEMBL

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