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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL66814
Molecular formulaC24H34INO5
IUPAC name4-pyridin-1-ium-1-ylbutyl 4-hexoxy-3,5-dimethoxybenzoate;iodide
Molecular weight543.442
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogPNone
SynonymsN/A
Inchi KeyBFEBCOPQIBLELO-UHFFFAOYSA-M
Inchi IDInChI=1S/C24H34NO5.HI/c1-4-5-6-11-16-29-23-21(27-2)18-20(19-22(23)28-3)24(26)30-17-12-10-15-25-13-8-7-9-14-25;/h7-9,13-14,18-19H,4-6,10-12,15-17H2,1-3H3;1H/q+1;/p-1
PubChem CID10370136
ChEMBLCHEMBL66814
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC50 ratio107.0 -PMID7783144ChEMBL
Ki851.14 nMPMID7783144ChEMBL
pKb7.08 -PMID7783144ChEMBL

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