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GPCR

NameOrexin receptor type 2
SpeciesRattus norvegicus (Rat)
GeneHcrtr2
Synonymhypocretin receptor 2
Hypocretin receptor type 2
hypocretin (orexin) receptor 2
orexin receptor type 2
Ox-2-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
UniProtP56719
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1275216
IUPHAR322
DrugBankN/A

Ligand

NameSCHEMBL1717503
Molecular formulaC23H23FN4O2
IUPAC name[(2R,5R)-5-[(5-fluoropyridin-2-yl)oxymethyl]-2-methylpiperidin-1-yl]-(2-pyrimidin-2-ylphenyl)methanone
Molecular weight406.461
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.5
SynonymsBDBM104706
US8569311, 1-28
CHEMBL3655679
Inchi KeyNHPFQONZHFJUNT-IAGOWNOFSA-N
Inchi IDInChI=1S/C23H23FN4O2/c1-16-7-8-17(15-30-21-10-9-18(24)13-27-21)14-28(16)23(29)20-6-3-2-5-19(20)22-25-11-4-12-26-22/h2-6,9-13,16-17H,7-8,14-15H2,1H3/t16-,17-/m1/s1
PubChem CID59396033
ChEMBLCHEMBL3655679
IUPHARN/A
BindingDB104706
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.67 nM, NoneBindingDB,ChEMBL

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