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GLASS

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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL214843
Molecular formula	C21H20ClN3O
IUPAC name	(E)-N-(4-amino-2-propylquinolin-6-yl)-3-(3-chlorophenyl)prop-2-enamide
Molecular weight	365.861
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	4.6
Synonyms	BDBM50193631 (E)-N-(4-amino-2-propylquinolin-6-yl)-3-(3-chlorophenyl)acrylamide
Inchi Key	BFLZUTXQMJOMAL-JXMROGBWSA-N
Inchi ID	InChI=1S/C21H20ClN3O/c1-2-4-16-13-19(23)18-12-17(8-9-20(18)24-16)25-21(26)10-7-14-5-3-6-15(22)11-14/h3,5-13H,2,4H2,1H3,(H2,23,24)(H,25,26)/b10-7+
PubChem CID	44417866
ChEMBL	CHEMBL214843
IUPHAR	N/A
BindingDB	50193631
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1100.0 nM	PMID16919453	BindingDB,ChEMBL

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