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Name | Leukotriene B4 receptor 2 |
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Species | Homo sapiens (Human) |
Gene | LTB4R2 |
Synonym | NOP9 12-HHT receptor Seven transmembrane receptor BLTR2 LTB4-R2 LTB4-R 2 [ Show all ] |
Disease | Inflammatory bowel disease |
Length | 358 |
Amino acid sequence | MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL |
UniProt | Q9NPC1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9NPC1 |
3D structure model | This predicted structure model is from GPCR-EXP Q9NPC1. |
BioLiP | N/A |
Therapeutic Target Database | T30563 |
ChEMBL | CHEMBL3191 |
IUPHAR | 268 |
DrugBank | BE0003489 |
Name | CHEMBL1094348 |
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Molecular formula | C38H39FO8 |
IUPAC name | 4-[3-[6-[3-(1,3-benzodioxol-5-yl)-5-(3-fluorophenyl)phenoxy]hexyl]-2-(2-carboxyethyl)phenoxy]butanoic acid |
Molecular weight | 642.72 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 8.4 |
Synonyms | NMNJWRKGTYNGSA-UHFFFAOYSA-N 4-{3-[6-(5-benzo[1,3]dioxol-5-yl-3'-fluoro-biphenyl-3-yloxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy}-butyric acid SCHEMBL1689717 4-(3-(6-(5-(benzo[d][1,3]dioxol-5-yl)-3''-fluorobiphenyl-3-yloxy)hexyl)-2-(2-carboxyethyl)phenoxy)butanoic acid BDBM50317623 |
Inchi Key | NMNJWRKGTYNGSA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C38H39FO8/c39-31-11-5-10-27(21-31)29-20-30(28-14-16-35-36(24-28)47-25-46-35)23-32(22-29)44-18-4-2-1-3-8-26-9-6-12-34(33(26)15-17-38(42)43)45-19-7-13-37(40)41/h5-6,9-12,14,16,20-24H,1-4,7-8,13,15,17-19,25H2,(H,40,41)(H,42,43) |
PubChem CID | 25192471 |
ChEMBL | CHEMBL1094348 |
IUPHAR | N/A |
BindingDB | 50317623 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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IC50 | 194.0 nM | PMID20380377 | BindingDB,ChEMBL |
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