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GPCR

NameProstaglandin E2 receptor EP1 subtype
SpeciesHomo sapiens (Human)
GenePTGER1
SynonymPGE receptor EP1 subtype
EP1 receptor
prostaglandin E receptor 1 (subtype EP1), 42kDa
Prostanoid EP1 receptor
EP1 prostanoid receptor
[ Show all ]
DiseaseUnspecified
Thrombosis
Pollakiuria
Pain
Length402
Amino acid sequenceMSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
UniProtP34995
Protein Data BankN/A
GPCR-HGmod modelP34995
3D structure modelThis predicted structure model is from GPCR-EXP P34995.
BioLiPN/A
Therapeutic Target DatabaseT15497
ChEMBLCHEMBL1811
IUPHAR340
DrugBankBE0000064

Ligand

NameCHEMBL212688
Molecular formulaC26H20F3NO3
IUPAC name3-[2-methyl-5-[2-phenylmethoxy-5-(trifluoromethyl)phenyl]pyrrol-1-yl]benzoic acid
Molecular weight451.445
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP6.3
Synonyms3-{2-[5-Trifluoromethyl-2-(benzyloxy)-phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid
BGHIUMTVMSHYKR-UHFFFAOYSA-N
SCHEMBL5627902
Inchi KeyBGHIUMTVMSHYKR-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H20F3NO3/c1-17-10-12-23(30(17)21-9-5-8-19(14-21)25(31)32)22-15-20(26(27,28)29)11-13-24(22)33-16-18-6-3-2-4-7-18/h2-15H,16H2,1H3,(H,31,32)
PubChem CID44413101
ChEMBLCHEMBL212688
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC505.012 nMPMID16697196ChEMBL

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