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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2b
Synonym	ADRA2L1 alpha2B-adrenoceptor alpha2B alpha2-C2 alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor Adra-2b adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 alpha-2B adrenergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	453
Amino acid sequence	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProt	P19328
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL266
IUPHAR	26
DrugBank	N/A

Ligand

Name	76537-53-6
Molecular formula	C10H13N5
IUPAC name	8-piperazin-1-ylimidazo[1,2-a]pyrazine
Molecular weight	203.249
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.5
Synonyms	ZINC5117657 AC1L2YVL D0E5CI 8-(piperazin-1-yl)imidazo[1,2-a]pyrazine AKOS024075563 Imidazo(1,2-a)pyrazine, 8-(1-piperazinyl)- L-639,019 1-{IMIDAZO[1,2-A]PYRAZIN-8-YL}PIPERAZINE 8-piperazin-1-ylimidazo[1,2-a]pyrazine CHEMBL331036 8-(1-Piperazinyl)imidazo(1,2-a)pyrazine AC1Q1I52 DTXSID50227346 Imidazo[1,2-a]pyrazine, 8-(1-piperazinyl)- 8-Pdpr BDBM50002151 SCHEMBL5496661 A839966 CTK5E3085 8-(1-piperazinyl)imidazo[1,2-a]pyrazine AC1Q4X6M FT-0756627 Imidazo[1,2-a]pyrazine,8-(1-piperazinyl)- 8-Piperazin-1-yl-imidazo[1,2-a]pyrazine [ Show all ]
Inchi Key	NSHLOJVJEGEMSF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H13N5/c1-5-14(6-2-11-1)9-10-13-4-8-15(10)7-3-12-9/h3-4,7-8,11H,1-2,5-6H2
PubChem CID	131268
ChEMBL	CHEMBL331036
IUPHAR	N/A
BindingDB	50002151
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	34.0 nM	PMID1656026	BindingDB

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