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GPCR

Name5-hydroxytryptamine receptor 2B
SpeciesRattus norvegicus (Rat)
GeneHtr2b
Synonymstomach fundus serotonin receptor
serotonin receptor 2B
5-HT-2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
5-HT2F
[ Show all ]
DiseaseN/A for non-human GPCRs
Length479
Amino acid sequenceMASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProtP30994
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL323
IUPHAR7
DrugBankN/A

Ligand

Name1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
Molecular formulaC11H16INO2
IUPAC name1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
Molecular weight321.158
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP2.5
Synonyms2,5-dimethoxy-4-iodoamphetamine hydrochloride
82830-53-3
BGMZUEKZENQUJY-UHFFFAOYSA-
D07XTU
GTPL147
[ Show all ]
Inchi KeyBGMZUEKZENQUJY-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H16INO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3
PubChem CID1229
ChEMBLCHEMBL6616
IUPHAR147
BindingDB28582
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki25.1189 nMPMID8078486, PMID8450835IUPHAR
Ki26.6 nMPMID8632342, PMID8078486, PMID9933142BindingDB
Ki27.54 nMPMID7984267BindingDB

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