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GPCR

Name5-hydroxytryptamine receptor 5B
SpeciesRattus norvegicus (Rat)
GeneHtr5b
SynonymMR22
HTR5B
GPR134
G protein-coupled receptor 134
5-HT-5B
[ Show all ]
DiseaseN/A for non-human GPCRs
Length370
Amino acid sequenceMEVSNLSGATPGIAFPPGPESCSDSPSSGRSMGSTPGGLILSGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASALMIAITWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAAKFRFGRRRRAVVPLPATTQAKEAPQESETVFTARCRATVAFQTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR
UniProtP35365
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2619
IUPHARN/A
DrugBankN/A

Ligand

Name1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
Molecular formulaC11H16INO2
IUPAC name1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
Molecular weight321.158
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP2.5
SynonymsNCGC00015302-04
SCHEMBL293580
2,5-dimethoxy-4-iodoamphetamine hydrochloride
82830-53-3
BGMZUEKZENQUJY-UHFFFAOYSA-
[ Show all ]
Inchi KeyBGMZUEKZENQUJY-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H16INO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3
PubChem CID1229
ChEMBLCHEMBL6616
IUPHAR147
BindingDB28582
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1000.0 nMPMID7682702BindingDB

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