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Name | Nociceptin receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Oprl1 |
Synonym | NOP receptor NOP-r NOPr OP4 Orphanin FQ receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 367 |
Amino acid sequence | MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA |
UniProt | P35370 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4503 |
IUPHAR | 320 |
DrugBank | N/A |
Name | CHEMBL186300 |
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Molecular formula | C28H30ClNO3 |
IUPAC name | methyl 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanoate |
Molecular weight | 464.002 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 5.4 |
Synonyms | BDBM50153611 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-butyric acid methyl ester |
Inchi Key | NVAROXIKIBRSFM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H30ClNO3/c1-33-26(31)28(23-8-4-2-5-9-23,24-10-6-3-7-11-24)18-21-30-19-16-27(32,17-20-30)22-12-14-25(29)15-13-22/h2-15,32H,16-21H2,1H3 |
PubChem CID | 44395306 |
ChEMBL | CHEMBL186300 |
IUPHAR | N/A |
BindingDB | 50153611 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | <75.0 % | PMID15454210 | ChEMBL |
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