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GLASS

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GPCR

Name	D(1A) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd1
Synonym	D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	P18901
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL265
IUPHAR	214
DrugBank	N/A

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	S0501 GTPL5501 5-22-08-00105 (Beilstein Handbook Reference) SR-01000075402-2 HMS3372O01 AKOS004912732 Sulpirida [INN-Spanish] Isnamide Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- SULPIRIDE,(+) Levopraid BPBio1_000463 Sulpyrid LP01050 Calmoflorine Zemorcon Miradol NCGC00024852-02 CHEMBL26 N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Norestran Desmenat Ozoderpin Dresent (+/-)-Sulpiride Pyrikappl Enimon 15676-16-1 Sernevin HMS2095K13 AB0105833 Stamonevrol HMS3712K13 AN-1019 Sulpiride 1.0 mg/ml in Methanol KBio1_000278 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Sulpiridum Levosulpiride [INN] BRD-A55272860-001-04-7 Synedil Magnetic resonance imaging sulpiride NCGC00015966-04 CCRIS 4248 MLS000069434 NCGC00024852-05 CTK8F2082 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- Dobren (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Prestwick2_000056 DSSTox_RID_80050 (plusmn)-sulpiride R.D. 1403 EU-0101050 RV-12309 Fidelan 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide Splotin HMS3266P12 AC1L1K62 Sulpirid I06-0054 BDBM11638 Sulpiride, European Pharmacopoeia (EP) Reference Standard L-Sulpiride Biomol-NT_000162 Sulpor Lisopiride BSPBio_000211 Valirem Meresa NCGC00015966-07 CHEBI:32168 N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Neogama Omperan Dogmatyl (TN) (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Psicocen Eglonyl (RS)-(A+/-)-Sulpiride s4655 Guastil SR-01000075402-3 HMS3393A08 Alimoral J10067 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- SULPIRIDE,(-) Levosulpirida BPBio1_001255 Suprium LS-20058 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide CAS-15676-16-1 Mirbanil NCGC00024852-03 Coolspan N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide Normum DivK1c_000278 ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Prestwick0_000056 DSSTox_CID_22574 (.+/-.)-Sulpiride Pyrkappl Equilid 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide SMR000038923 HMS2231K07 Abilit STK368596 HMS500N20 BCP04500 Sulpiride [USAN:INN:BAN:JAN] KS-00000YBQ BGRJTUBHPOOWDU-UHFFFAOYSA-N Sulpiridum [INN-Latin] Levosulpiridum BRD-A55272860-001-08-8 Tox21_302205 Mariastel NCGC00015966-05 CCRIS-4248 MLS001306443 NCGC00255813-01 D01226 o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- Dogmatil (+-)-sulpiride Prestwick3_000056 DTXSID1042574 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide RD 1403 Eusulpid S 8010 FT-0652244 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide SR-01000075402 HMS3371P16 Aiglonyl Sulpirida IDI1_000278 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- Sulpiride, SLP L000579 BPBio1_000233 Sulpride Lopac0_001050 C15H23N3O4S Z84655412 MFCD00055061 NCGC00015966-08 N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide NINDS_000278 DB00391 Oprea1_602476 Dolmatil (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide PubChem17241 EINECS 239-753-7 (y)-Sulpiride SCHEMBL8421 HMS1568K13 676S161 SR-01000075402-6 HMS3651G12 AN-1017 Sulpiride (JP17/USAN/INN) KB-295026 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- Sulpiride-R Levosulpirida [INN-Spanish] BRD-A55272860-001-03-9 Sursumid LS-20059 NCGC00015966-03 CCG-205127 Misulvan NCGC00024852-04 CS-4534 N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Nufarol dl-sulpiride ( inverted question mark)-Sulpiride Prestwick1_000056 DSSTox_GSID_42574 (?)-Sulpiride R. D. 1403 EU-0001755 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide SPBio_002132 HMS3263A22 AC-12181 Sulperide HY-B1019 BCP13871 Sulpiride, British Pharmacopoeia (BP) Reference Standard Kylistro Biomol-NT_000037 Sulpitil Levosulpiridum [INN-Latin] BRN 0494008 Tox21_501050 MCULE-7506797476 NCGC00015966-06 Championyl MolPort-002-070-475 NCGC00261735-01 Darleton Omiryl Dogmatyl (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Prestwick_431 Eglonil (RS)-(+/-)-sulpiride Restful Fardalan [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID6387355, PMID2869639	BindingDB

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