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GPCR

NameD(2) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD2
Synonymdopamine receptor 2
Dopamine D2 receptor
D2R
D2A and D2B
D2(415) and D2(444)
[ Show all ]
DiseaseSubstance dependence
Major depressive disorder
Maintain blood pressure in hypotensive states
Insomnia
Inflammatory disease
[ Show all ]
Length443
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP14416
Protein Data Bank6cm4, 6c38
GPCR-HGmod modelP14416
3D structure modelThis structure is from PDB ID 6cm4.
BioLiPBL0408379, BL0403379
Therapeutic Target DatabaseT67162
ChEMBLCHEMBL217
IUPHAR215
DrugBankBE0000756

Ligand

Namesulpiride
Molecular formulaC15H23N3O4S
IUPAC nameN-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight341.426
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP0.6
SynonymsEglonil
Sulpiridum [INN-Latin]
(RS)-(+/-)-sulpiride
Fardalan
Tox21_302205
[ Show all ]
Inchi KeyBGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID5355
ChEMBLCHEMBL26
IUPHAR5501
BindingDB11638
DrugBankDB00391

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank
Emax-6.26 %PMID22632094ChEMBL
IC5010.28 nMPMID21495689BindingDB,ChEMBL
IC50205.0 nMDrugMatrix in vitro pharmacology dataChEMBL
Ki4.2 nMPMID9686407PDSP,BindingDB
Ki6.0 nMPMID8301582PDSP,BindingDB
Ki7.6 nMMedChemComm, (2011) 2:10:935ChEMBL
Ki8.6 nMPMID16135699PDSP,BindingDB
Ki10.0 nMPMID1586393PDSP,BindingDB
Ki11.0 nMPMID16135699PDSP,BindingDB
Ki12.0 - 60.0 nMPMID7576010IUPHAR
Ki38.0 nMPMID8097160PDSP,BindingDB
Ki46.0 nMPMID2137193PDSP,BindingDB
Ki68.0 nMDrugMatrix in vitro pharmacology dataChEMBL
Ki120.0 nMPMID15689154BindingDB,ChEMBL
Ki206.0 nMPMID2532362PDSP,BindingDB
Ki520.0 nMPMID8301582PDSP,BindingDB
Ki684.0 nMPMID8097160PDSP,BindingDB
Ki5450.0 nMPMID2137193PDSP,BindingDB

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