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GLASS

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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	Sulperide Sulpiride, British Pharmacopoeia (BP) Reference Standard Sulpitil Tox21_501050 NCGC00015966-06 NCGC00261735-01 Omiryl Prestwick_431 Restful SPBio_002132 BRD-A55272860-001-04-7 Magnetic resonance imaging sulpiride CCRIS 4248 MLS000069434 CTK8F2082 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Dobren (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide DSSTox_RID_80050 (plusmn)-sulpiride EU-0101050 15676-16-1 HMS2095K13 AB0105833 HMS3712K13 AN-1019 KBio1_000278 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpiride [INN] Sulpirida [INN-Spanish] SULPIRIDE,(+) Sulpyrid Zemorcon NCGC00024852-02 Norestran Ozoderpin Pyrikappl S0501 SR-01000075402-2 Lisopiride BSPBio_000211 Meresa CHEBI:32168 N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Dogmatyl (TN) (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Eglonyl (RS)-(A+/-)-Sulpiride Fidelan 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide HMS3266P12 AC1L1K62 I06-0054 BDBM11638 L-Sulpiride Biomol-NT_000162 Stamonevrol Sulpiride 1.0 mg/ml in Methanol Sulpiridum Synedil NCGC00015966-04 NCGC00024852-05 o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- Prestwick2_000056 R.D. 1403 Sernevin BPBio1_001255 LS-20058 CAS-15676-16-1 Mirbanil Coolspan N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide DivK1c_000278 ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide DSSTox_CID_22574 (.+/-.)-Sulpiride Equilid 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Guastil HMS3393A08 Alimoral J10067 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpirida Sulpirid Sulpiride, European Pharmacopoeia (EP) Reference Standard Sulpor Valirem NCGC00015966-07 Neogama Omperan Psicocen RV-12309 Splotin Levosulpiridum BRD-A55272860-001-08-8 Mariastel CCRIS-4248 MLS001306443 D01226 Dogmatil (+-)-sulpiride DTXSID1042574 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eusulpid 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide HMS2231K07 Abilit HMS500N20 BCP04500 KS-00000YBQ BGRJTUBHPOOWDU-UHFFFAOYSA-N SULPIRIDE,(-) Suprium N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide NCGC00024852-03 Normum Prestwick0_000056 Pyrkappl s4655 SR-01000075402-3 Lopac0_001050 C15H23N3O4S MFCD00055061 N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide DB00391 Dolmatil (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide EINECS 239-753-7 (y)-Sulpiride FT-0652244 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide HMS3371P16 Aiglonyl IDI1_000278 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- L000579 BPBio1_000233 STK368596 Sulpiride [USAN:INN:BAN:JAN] Sulpiridum [INN-Latin] Tox21_302205 NCGC00015966-05 NCGC00255813-01 o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- Prestwick3_000056 RD 1403 SMR000038923 BRD-A55272860-001-03-9 LS-20059 CCG-205127 Misulvan CS-4534 N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide dl-sulpiride ( inverted question mark)-Sulpiride DSSTox_GSID_42574 (?)-Sulpiride EU-0001755 HMS1568K13 676S161 HMS3651G12 AN-1017 KB-295026 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- Levosulpirida [INN-Spanish] Sulpirida Sulpiride, SLP Sulpride Z84655412 NCGC00015966-08 NINDS_000278 Oprea1_602476 PubChem17241 S 8010 SR-01000075402 Levosulpiridum [INN-Latin] BRN 0494008 MCULE-7506797476 Championyl MolPort-002-070-475 Darleton Dogmatyl (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eglonil (RS)-(+/-)-sulpiride Fardalan 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide HMS3263A22 AC-12181 HY-B1019 BCP13871 Kylistro Biomol-NT_000037 Sulpiride (JP17/USAN/INN) Sulpiride-R Sursumid NCGC00015966-03 NCGC00024852-04 Nufarol Prestwick1_000056 R. D. 1403 SCHEMBL8421 SR-01000075402-6 BPBio1_000463 LP01050 Calmoflorine Miradol CHEMBL26 N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Desmenat Dresent (+/-)-Sulpiride Enimon GTPL5501 5-22-08-00105 (Beilstein Handbook Reference) HMS3372O01 AKOS004912732 Isnamide Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- Levopraid [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Emax	-6.83 %	PMID22632094	ChEMBL
IC50	66.22 nM	PMID21495689	BindingDB,ChEMBL
IC50	169.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
IC50	560.0 nM	PMID21495689	BindingDB,ChEMBL
Ki	7.9 nM	PMID16135699	PDSP,BindingDB
Ki	8.0 nM	PMID14521403, PMID8301582	PDSP,BindingDB,ChEMBL
Ki	8.2 nM	PMID16135699	PDSP,BindingDB
Ki	14.0 - 142.0 nM	PMID7576010	IUPHAR
Ki	15.0 nM	PMID9686407	PDSP,BindingDB
Ki	20.0 nM	PMID1586393	PDSP,BindingDB
Ki	57.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	120.0 nM	PMID15689154	BindingDB,ChEMBL
Ki	480.0 nM	PMID8301582	PDSP,BindingDB

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