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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Ligand

Namesulpiride
Molecular formulaC15H23N3O4S
IUPAC nameN-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight341.426
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP0.6
SynonymsSulpiride, SLP
Sulpride
Z84655412
NCGC00015966-08
NINDS_000278
[ Show all ]
Inchi KeyBGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID5355
ChEMBLCHEMBL26
IUPHAR5501
BindingDB11638
DrugBankDB00391

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5033.0 nMPMID3172140BindingDB,ChEMBL
IC5036.0 nMPMID3172140BindingDB,ChEMBL
IC50210.0 nMPMID7901417BindingDB,ChEMBL
IC50233.0 nMPMID4040977BindingDB,ChEMBL
Kd1.5 nMPMID2966245BindingDB,ChEMBL
Ki0.21 nMPMID10327430BindingDB
Ki2.5 nMPMID11171942BindingDB
Ki5.51 nMPMID2522993BindingDB,ChEMBL
Ki6.58 nMPMID2531826BindingDB
Ki8.2 nMPMID8278895BindingDB
Ki9.2 nMPMID1975644BindingDB
Ki10.2 nMPMID8278895BindingDB
Ki10.5 nMPMID8278895BindingDB
Ki23.0 nMPMID2138666, PMID3828800BindingDB
Ki24.0 nMPMID2958621BindingDB
Ki42.0 nMPMID2138666BindingDB
Ki57.0 nMPMID8301592BindingDB
Ki70.0 nMPMID2958621BindingDB
Ki71.6 nMPMID8301592BindingDB
Ki78.0 nMPMID10327430BindingDB
Ki85.0 nMPMID1975644BindingDB
Ki122.0 nMPMID2869639BindingDB
Ki150.0 nMPMID3130534BindingDB
Ki160.0 nMPMID2532362BindingDB
Ki180.0 nMPMID6655559BindingDB
Ki205.0 nMPMID2532362BindingDB
Ki233.0 nMPMID2869639BindingDB
Ki240.0 nMPMID9748351BindingDB,ChEMBL
Ki320.0 nMPMID6655559BindingDB
Ki340.0 nMPMID10327430BindingDB
Ki518.0 nMPMID3828800BindingDB
Ki636.0 nMPMID1356154BindingDB
Ki730.0 nMPMID2869639BindingDB
Ki1102.0 nMPMID6387355BindingDB

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