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GLASS

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GPCR

Name	D(1B) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD5
Synonym	Gpcr1 DRD1L2 DRD1B dopamine receptor 5 Dopamine D5 receptor D5 receptor D1beta dopamine receptor D(5) dopamine receptor D(1B) dopamine receptor [ Show all ]
Disease	Solid tumours Schizophrenia
Length	477
Amino acid sequence	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProt	P21918
Protein Data Bank	N/A
GPCR-HGmod model	P21918
3D structure model	This predicted structure model is from GPCR-EXP P21918.
BioLiP	N/A
Therapeutic Target Database	T46828
ChEMBL	CHEMBL1850
IUPHAR	218
DrugBank	BE0000145, BE0004889

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	R. D. 1403 KB-295026 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- SCHEMBL8421 Levosulpirida [INN-Spanish] BRD-A55272860-001-03-9 SR-01000075402-6 LS-20059 CCG-205127 Sulpiride (JP17/USAN/INN) Misulvan CS-4534 Sulpiride-R N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide dl-sulpiride Sursumid ( inverted question mark)-Sulpiride NCGC00015966-03 DSSTox_GSID_42574 (?)-Sulpiride NCGC00024852-04 EU-0001755 Nufarol HMS1568K13 676S161 Prestwick1_000056 HMS3651G12 AN-1017 Restful Kylistro Biomol-NT_000037 SPBio_002132 Levosulpiridum [INN-Latin] BRN 0494008 Sulperide MCULE-7506797476 Championyl Sulpiride, British Pharmacopoeia (BP) Reference Standard MolPort-002-070-475 Darleton Sulpitil Dogmatyl Tox21_501050 (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide NCGC00015966-06 Eglonil (RS)-(+/-)-sulpiride NCGC00261735-01 Fardalan 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide Omiryl HMS3263A22 AC-12181 Prestwick_431 HY-B1019 BCP13871 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- S0501 Levopraid BPBio1_000463 SR-01000075402-2 LP01050 Calmoflorine Sulpirida [INN-Spanish] Miradol CHEMBL26 SULPIRIDE,(+) N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Desmenat Sulpyrid Dresent Zemorcon (+/-)-Sulpiride NCGC00024852-02 Enimon Norestran GTPL5501 5-22-08-00105 (Beilstein Handbook Reference) Ozoderpin HMS3372O01 AKOS004912732 Pyrikappl Isnamide R.D. 1403 KBio1_000278 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Sernevin Levosulpiride [INN] BRD-A55272860-001-04-7 Stamonevrol Magnetic resonance imaging sulpiride CCRIS 4248 Sulpiride 1.0 mg/ml in Methanol MLS000069434 CTK8F2082 Sulpiridum N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Dobren Synedil (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide NCGC00015966-04 DSSTox_RID_80050 (plusmn)-sulpiride NCGC00024852-05 EU-0101050 15676-16-1 o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- HMS2095K13 AB0105833 Prestwick2_000056 HMS3712K13 AN-1019 BDBM11638 RV-12309 L-Sulpiride Biomol-NT_000162 Splotin Lisopiride BSPBio_000211 Sulpirid Meresa CHEBI:32168 Sulpiride, European Pharmacopoeia (EP) Reference Standard N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Sulpor Dogmatyl (TN) Valirem (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide NCGC00015966-07 Eglonyl (RS)-(A+/-)-Sulpiride Neogama Fidelan 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide Omperan HMS3266P12 AC1L1K62 Psicocen I06-0054 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- s4655 Levosulpirida BPBio1_001255 SR-01000075402-3 LS-20058 CAS-15676-16-1 Mirbanil Coolspan SULPIRIDE,(-) N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide DivK1c_000278 Suprium ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide DSSTox_CID_22574 (.+/-.)-Sulpiride NCGC00024852-03 Equilid 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Normum Guastil Prestwick0_000056 HMS3393A08 Alimoral Pyrkappl J10067 RD 1403 KS-00000YBQ BGRJTUBHPOOWDU-UHFFFAOYSA-N SMR000038923 Levosulpiridum BRD-A55272860-001-08-8 STK368596 Mariastel CCRIS-4248 Sulpiride [USAN:INN:BAN:JAN] MLS001306443 D01226 Sulpiridum [INN-Latin] Dogmatil Tox21_302205 (+-)-sulpiride NCGC00015966-05 DTXSID1042574 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide NCGC00255813-01 Eusulpid 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- HMS2231K07 Abilit Prestwick3_000056 HMS500N20 BCP04500 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- S 8010 L000579 BPBio1_000233 SR-01000075402 Lopac0_001050 C15H23N3O4S Sulpirida MFCD00055061 Sulpiride, SLP N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide DB00391 Sulpride Dolmatil Z84655412 (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide NCGC00015966-08 EINECS 239-753-7 (y)-Sulpiride NINDS_000278 FT-0652244 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide Oprea1_602476 HMS3371P16 Aiglonyl PubChem17241 IDI1_000278 [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID1826762	PDSP,BindingDB

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