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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Sulpitil Tox21_501050 Dogmatyl (TN) NCGC00015966-06 (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Eglonyl NCGC00261735-01 (RS)-(A+/-)-Sulpiride Fidelan Omiryl 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide HMS3266P12 Prestwick_431 AC1L1K62 I06-0054 Restful BDBM11638 L-Sulpiride SPBio_002132 Biomol-NT_000162 Lisopiride Sulperide BSPBio_000211 Meresa Sulpiride, British Pharmacopoeia (BP) Reference Standard CHEBI:32168 Coolspan N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide Sulpyrid DivK1c_000278 ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Zemorcon DSSTox_CID_22574 NCGC00024852-02 (.+/-.)-Sulpiride Equilid Norestran 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Guastil Ozoderpin HMS3393A08 Pyrikappl Alimoral J10067 S0501 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpirida SR-01000075402-2 BPBio1_001255 LS-20058 Sulpirida [INN-Spanish] CAS-15676-16-1 Mirbanil SULPIRIDE,(+) MLS001306443 Sulpiridum D01226 Synedil Dogmatil NCGC00015966-04 (+-)-sulpiride DTXSID1042574 NCGC00024852-05 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eusulpid o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide HMS2231K07 Prestwick2_000056 Abilit HMS500N20 R.D. 1403 BCP04500 KS-00000YBQ Sernevin BGRJTUBHPOOWDU-UHFFFAOYSA-N Levosulpiridum Stamonevrol BRD-A55272860-001-08-8 Mariastel Sulpiride 1.0 mg/ml in Methanol CCRIS-4248 N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide Sulpor DB00391 Valirem Dolmatil NCGC00015966-07 (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide EINECS 239-753-7 Neogama (y)-Sulpiride FT-0652244 Omperan 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide HMS3371P16 Psicocen Aiglonyl IDI1_000278 RV-12309 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- L000579 Splotin BPBio1_000233 Lopac0_001050 Sulpirid C15H23N3O4S MFCD00055061 Sulpiride, European Pharmacopoeia (EP) Reference Standard SULPIRIDE,(-) CS-4534 N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Suprium dl-sulpiride N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide ( inverted question mark)-Sulpiride DSSTox_GSID_42574 NCGC00024852-03 (?)-Sulpiride EU-0001755 Normum HMS1568K13 Prestwick0_000056 676S161 HMS3651G12 Pyrkappl AN-1017 KB-295026 s4655 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- Levosulpirida [INN-Spanish] SR-01000075402-3 BRD-A55272860-001-03-9 LS-20059 CCG-205127 Misulvan MolPort-002-070-475 Sulpiridum [INN-Latin] Darleton Tox21_302205 Dogmatyl NCGC00015966-05 (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eglonil NCGC00255813-01 (RS)-(+/-)-sulpiride Fardalan o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide HMS3263A22 Prestwick3_000056 AC-12181 HY-B1019 RD 1403 BCP13871 Kylistro SMR000038923 Biomol-NT_000037 Levosulpiridum [INN-Latin] STK368596 BRN 0494008 MCULE-7506797476 Sulpiride [USAN:INN:BAN:JAN] Championyl CHEMBL26 N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Sulpride Desmenat Z84655412 Dresent NCGC00015966-08 (+/-)-Sulpiride Enimon NINDS_000278 GTPL5501 Oprea1_602476 5-22-08-00105 (Beilstein Handbook Reference) HMS3372O01 PubChem17241 AKOS004912732 Isnamide S 8010 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- Levopraid SR-01000075402 BPBio1_000463 LP01050 Sulpirida Calmoflorine Miradol Sulpiride, SLP Sulpiride-R CTK8F2082 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Sursumid Dobren NCGC00015966-03 (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide DSSTox_RID_80050 NCGC00024852-04 (plusmn)-sulpiride EU-0101050 Nufarol 15676-16-1 HMS2095K13 Prestwick1_000056 AB0105833 HMS3712K13 R. D. 1403 AN-1019 KBio1_000278 SCHEMBL8421 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpiride [INN] SR-01000075402-6 BRD-A55272860-001-04-7 Magnetic resonance imaging sulpiride Sulpiride (JP17/USAN/INN) CCRIS 4248 MLS000069434 [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID1347569, PMID9686407	BindingDB

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