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GLASS

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GPCR

Name	D(1A) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd1
Synonym	D1 receptor D1A DADR Dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	Q61616
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3071
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	BCP13871 o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- Kylistro Biomol-NT_000037 Prestwick3_000056 Levosulpiridum [INN-Latin] BRN 0494008 RD 1403 MCULE-7506797476 Championyl SMR000038923 MolPort-002-070-475 Darleton STK368596 Dogmatyl Sulpiride [USAN:INN:BAN:JAN] (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eglonil Sulpiridum [INN-Latin] (RS)-(+/-)-sulpiride Fardalan Tox21_302205 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide NCGC00015966-05 HMS3263A22 AC-12181 NCGC00255813-01 HY-B1019 NINDS_000278 Isnamide Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- Oprea1_602476 Levopraid BPBio1_000463 PubChem17241 LP01050 Calmoflorine S 8010 Miradol CHEMBL26 SR-01000075402 N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Desmenat Sulpirida Dresent Sulpiride, SLP (+/-)-Sulpiride Enimon Sulpride GTPL5501 Z84655412 5-22-08-00105 (Beilstein Handbook Reference) NCGC00015966-08 HMS3372O01 AKOS004912732 AN-1019 Nufarol KBio1_000278 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Prestwick1_000056 Levosulpiride [INN] BRD-A55272860-001-04-7 R. D. 1403 Magnetic resonance imaging sulpiride CCRIS 4248 SCHEMBL8421 MLS000069434 CTK8F2082 SR-01000075402-6 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Dobren Sulpiride (JP17/USAN/INN) (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide DSSTox_RID_80050 Sulpiride-R (plusmn)-sulpiride EU-0101050 Sursumid 15676-16-1 NCGC00015966-03 HMS2095K13 AB0105833 NCGC00024852-04 HMS3712K13 BDBM11638 Omiryl L-Sulpiride Biomol-NT_000162 Prestwick_431 Lisopiride BSPBio_000211 Restful Meresa CHEBI:32168 SPBio_002132 N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Sulperide Dogmatyl (TN) Sulpiride, British Pharmacopoeia (BP) Reference Standard (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Eglonyl Sulpitil (RS)-(A+/-)-Sulpiride Fidelan Tox21_501050 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide NCGC00015966-06 HMS3266P12 AC1L1K62 NCGC00261735-01 I06-0054 Norestran J10067 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Ozoderpin Levosulpirida BPBio1_001255 Pyrikappl LS-20058 CAS-15676-16-1 S0501 Mirbanil Coolspan SR-01000075402-2 N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide DivK1c_000278 Sulpirida [INN-Spanish] ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide DSSTox_CID_22574 SULPIRIDE,(+) (.+/-.)-Sulpiride Equilid Sulpyrid 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Guastil Zemorcon NCGC00024852-02 HMS3393A08 Alimoral BCP04500 o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- KS-00000YBQ BGRJTUBHPOOWDU-UHFFFAOYSA-N Prestwick2_000056 Levosulpiridum BRD-A55272860-001-08-8 R.D. 1403 Mariastel CCRIS-4248 Sernevin MLS001306443 D01226 Stamonevrol Dogmatil Sulpiride 1.0 mg/ml in Methanol (+-)-sulpiride DTXSID1042574 Sulpiridum (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eusulpid Synedil 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide NCGC00015966-04 HMS2231K07 Abilit NCGC00024852-05 HMS500N20 IDI1_000278 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- Omperan L000579 BPBio1_000233 Psicocen Lopac0_001050 C15H23N3O4S RV-12309 MFCD00055061 Splotin N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide DB00391 Sulpirid Dolmatil Sulpiride, European Pharmacopoeia (EP) Reference Standard (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide EINECS 239-753-7 Sulpor (y)-Sulpiride FT-0652244 Valirem 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide NCGC00015966-07 HMS3371P16 Aiglonyl Neogama Normum KB-295026 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- Prestwick0_000056 Levosulpirida [INN-Spanish] BRD-A55272860-001-03-9 Pyrkappl LS-20059 CCG-205127 s4655 Misulvan CS-4534 SR-01000075402-3 N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide dl-sulpiride ( inverted question mark)-Sulpiride DSSTox_GSID_42574 SULPIRIDE,(-) (?)-Sulpiride EU-0001755 Suprium N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide HMS1568K13 676S161 NCGC00024852-03 HMS3651G12 AN-1017 [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID2895008	BindingDB

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