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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	CHEMBL562477
Molecular formula	C15H22ClN3O3
IUPAC name	4-amino-5-chloro-N-[1-(2-hydroxyethyl)piperidin-4-yl]-2-methoxybenzamide
Molecular weight	327.809
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	1.8
Synonyms	BDBM50414685 SCHEMBL10486812
Inchi Key	BGUPBAJOPHUCTR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H22ClN3O3/c1-22-14-9-13(17)12(16)8-11(14)15(21)18-10-2-4-19(5-3-10)6-7-20/h8-10,20H,2-7,17H2,1H3,(H,18,21)
PubChem CID	20030109
ChEMBL	CHEMBL562477
IUPHAR	N/A
BindingDB	50414685
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	63.1 nM	PMID19663444	BindingDB,ChEMBL
Intrinsic activity	<100.0 %	PMID19663444	ChEMBL
Ki	199.53 nM	PMID19663444	ChEMBL
Ki	200.0 nM	PMID19663444	BindingDB

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