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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | 158985-00-3 |
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Molecular formula | C18H19ClN4 |
IUPAC name | 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine |
Molecular weight | 326.828 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 3.4 |
Synonyms | 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine BRD-K05528470-001-01-9 CPMPP-3 L-745,870 NCGC00015588-01 [ Show all ] |
Inchi Key | OGJGQVFWEPNYSB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21) |
PubChem CID | 5311200 |
ChEMBL | CHEMBL267014 |
IUPHAR | 3303 |
BindingDB | 85093 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 360.0 nM | PMID9873481 | BindingDB |
Ki | <10000.0 nM | PMID19481941 | PDSP |
Ki | 343.0 nM | PMID16135699 | PDSP,BindingDB |
Ki | 448.0 nM | PMID15084133 | BindingDB,ChEMBL |
Ki | 908.0 nM | PMID10602703, PMID9873377 | BindingDB,ChEMBL |
Ki | 920.0 nM | PMID9822559 | BindingDB,ChEMBL |
Ki | 960.0 nM | PMID19155177, PMID8642550, PMID10098669, PMID15501032, PMID24800940 | PDSP,BindingDB,ChEMBL |
Ki | 38000.0 nM | PMID11844688, PMID19481941 | BindingDB,ChEMBL |
Ki | 53703.2 nM | PMID17266201 | ChEMBL |
Ki | 54000.0 nM | PMID11844688, PMID19481941 | BindingDB,ChEMBL |
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