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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	158985-00-3
Molecular formula	C18H19ClN4
IUPAC name	3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine
Molecular weight	326.828
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.4
Synonyms	C099630000 DA-09764 L000337 NCGC00015588-03 PDSP2_001560 UNII-J3OLN3XSX7 3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine BDBM85093 CHEBI:92099 GTPL3303 Lopac0_000791 NCGC00024931-01 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine BRD-K05528470-001-01-9 CPMPP-3 L-745,870 NCGC00015588-01 NSC_3853 SCHEMBL1059886 1H-Pyrrolo[2,3-b]pyridine,3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]- AC1NSK75 CAS_3853 DTXSID40415513 L745870 NCGC00015588-04 ZINC95803215 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride Biomol-NT_000049 J3OLN3XSX7 LS-186986 NCGC00024931-02 BRD-K05528470-305-01-4 D0N1HW L-745870 NCGC00015588-02 PDSP1_001576 Tocris-1002 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine API0003103 CCG-204875 FT-0689275 Lopac-L-131 NCGC00015588-05 3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-pyrrolo[2,3-b]pyridine BPBio1_001299 CHEMBL267014 L 745,870 LS-187628 NCGC00024931-03 [ Show all ]
Inchi Key	OGJGQVFWEPNYSB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
PubChem CID	5311200
ChEMBL	CHEMBL267014
IUPHAR	3303
BindingDB	85093
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID11378358	BindingDB,ChEMBL

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