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GPCR

NameP2Y purinoceptor 1
SpeciesRattus norvegicus (Rat)
GeneP2ry1
SynonymATP receptor
purinergic receptor P2Y
Purinergic receptor
platelet ADP receptor
P2Y1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length373
Amino acid sequenceMTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL
UniProtP49651
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2497
IUPHARN/A
DrugBankN/A

Ligand

NameDiadenosine Pentaphosphate
Molecular formulaC20H29N10O22P5
IUPAC namebis[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
Molecular weight916.369
Hydrogen bond acceptor30
Hydrogen bond donor11
XlogP-9.4
SynonymsAC1L98W4
ApppppA
CHEMBL437508
P1,P5-Bis(5'-adenosyl) pentaphosphate
128113-55-3
[ Show all ]
Inchi KeyOIMACDRJUANHTJ-XPWFQUROSA-N
Inchi IDInChI=1S/C20H29N10O22P5/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(47-19)1-45-53(35,36)49-55(39,40)51-57(43,44)52-56(41,42)50-54(37,38)46-2-8-12(32)14(34)20(48-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1
PubChem CID440210
ChEMBLCHEMBL437508
IUPHARN/A
BindingDB50435017
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC505000.0 nMPMID16539385ChEMBL

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