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GPCR

NamePyroglutamylated RF-amide peptide receptor
SpeciesHomo sapiens (Human)
GeneQRFPR
SynonymQRFP receptor
peptide p518 receptor
Orexigenic neuropeptide QRFP receptor
GPR103
G-protein coupled receptor 103
[ Show all ]
DiseaseN/A
Length431
Amino acid sequenceMQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProtQ96P65
Protein Data BankN/A
GPCR-HGmod modelQ96P65
3D structure modelThis predicted structure model is from GPCR-EXP Q96P65.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5852
IUPHAR333
DrugBankN/A

Ligand

NameCHEMBL2170396
Molecular formulaC42H58N12O9
IUPAC name(2S)-2-[[(2S)-2-[[2-[[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-(2,3-dihydroxypropyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide
Molecular weight875.001
Hydrogen bond acceptor12
Hydrogen bond donor12
XlogP-1.6
SynonymsBDBM50396428
Inchi KeyOKGLWUOAPMXSNZ-ILZVRDPESA-N
Inchi IDInChI=1S/C42H58N12O9/c43-22-35(57)48-23-36(58)49-34(21-29-15-8-3-9-16-29)41(63)53-54(24-30(56)26-55)25-37(59)50-33(20-28-13-6-2-7-14-28)40(62)51-31(17-10-18-47-42(45)46)39(61)52-32(38(44)60)19-27-11-4-1-5-12-27/h1-9,11-16,30-34,55-56H,10,17-26,43H2,(H2,44,60)(H,48,57)(H,49,58)(H,50,59)(H,51,62)(H,52,61)(H,53,63)(H4,45,46,47)/t30?,31-,32-,33-,34-/m0/s1
PubChem CID71449832
ChEMBLCHEMBL2170396
IUPHARN/A
BindingDB50396428
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50341.0 nMPMID22800498BindingDB,ChEMBL

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