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GPCR

NameD(1B) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd5
SynonymDRD1L2
DRD1B
dopamine receptor 5
Dopamine D5 receptor
D5 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length475
Amino acid sequenceMLPPGRNRTAQPARLGLQRQLAQVDAPAGSATPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGTFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVGLAWTLSILISFIPVQLNWHRDKAGSQGQEGLLSNGTPWEEGWELEGRTENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSRGAYEPDPSLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGDAEGPKTGFPCVSETTFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHFCFRTPVQTVNISNELISYNQDTVFHKEIATAYVHMIPNAVSSGDREVGEEEEEGPFDHMSQISPTTPDGDLAAESVWELDCEEEVSLGKISPLTPNCFDKTA
UniProtP25115
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2281
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL282424
Molecular formulaC18H19FN4
IUPAC name3-[[4-(2-fluorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine
Molecular weight310.376
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.8
Synonyms3-{[4-(2-fluorophenyl)-1-piperazinyl]methyl}-1H-pyrrolo[2,3-b]pyridine
SCHEMBL5196558
3-[4-(2-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-pyrrolo[2,3-b]pyridine
BDBM50099887
OOKNJSVAHXTYKL-UHFFFAOYSA-N
Inchi KeyOOKNJSVAHXTYKL-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H19FN4/c19-16-5-1-2-6-17(16)23-10-8-22(9-11-23)13-14-12-21-18-15(14)4-3-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
PubChem CID22065997
ChEMBLCHEMBL282424
IUPHARN/A
BindingDB50099887
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID11378358BindingDB,ChEMBL

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