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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL166102
Molecular formulaC15H18BrN3
IUPAC nameN-(2-bromo-4-ethylphenyl)-N,4,6-trimethylpyrimidin-2-amine
Molecular weight320.234
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.5
SynonymsZINC13794379
BDBM50074398
N,4,6-Trimethyl-N-(2-bromo-4-ethylphenyl)pyrimidine-2-amine
(2-Bromo-4-ethyl-phenyl)-(4,6-dimethyl-pyrimidin-2-yl)-methyl-amine
SCHEMBL7680278
Inchi KeyBJBJQLPFJLBRHO-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H18BrN3/c1-5-12-6-7-14(13(16)9-12)19(4)15-17-10(2)8-11(3)18-15/h6-9H,5H2,1-4H3
PubChem CID10663467
ChEMBLCHEMBL166102
IUPHARN/A
BindingDB50074398
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki187.0 nMPMID10072679BindingDB,ChEMBL

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