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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Ligand

NameCHEMBL372721
Molecular formulaC26H28Cl2N4O
IUPAC name1-[(1S,2R,5S)-5-(4-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-(3,5-dichlorophenyl)-1-(2-pyrrolidin-1-ylethyl)urea
Molecular weight483.437
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.3
SynonymsBDBM50164245
1-[(1S,2R,5S)-5-(4-Cyano-phenyl)-bicyclo[3.1.0]hex-2-yl]-3-(3,5-dichloro-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-urea
Inchi KeyBJNIDUIQWUGXOW-DGWZTRNLSA-N
Inchi IDInChI=1S/C26H28Cl2N4O/c27-20-13-21(28)15-22(14-20)30-25(33)32(12-11-31-9-1-2-10-31)24-7-8-26(16-23(24)26)19-5-3-18(17-29)4-6-19/h3-6,13-15,23-24H,1-2,7-12,16H2,(H,30,33)/t23-,24-,26-/m1/s1
PubChem CID10195667
ChEMBLCHEMBL372721
IUPHARN/A
BindingDB50164245
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<3000.0 nMPMID15801820BindingDB,ChEMBL

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