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GPCR

NamefMet-Leu-Phe receptor
SpeciesHomo sapiens (Human)
GeneFPR1
SynonymNFPR
N-formylpeptide chemoattractant receptor
N-formyl peptide receptor
FPR1
FPR
[ Show all ]
DiseaseInflammatory disease
Peptic ulcer
Length350
Amino acid sequenceMETNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProtP21462
Protein Data BankN/A
GPCR-HGmod modelP21462
3D structure modelThis predicted structure model is from GPCR-EXP P21462.
BioLiPN/A
Therapeutic Target DatabaseT87831
ChEMBLCHEMBL3359
IUPHAR222
DrugBankBE0000995

Ligand

NameMLS000047151
Molecular formulaC11H10N2O4S2
IUPAC namemethyl 1-(2,1,3-benzothiadiazol-4-ylsulfonyl)cyclopropane-1-carboxylate
Molecular weight298.331
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP1.3
SynonymsBDBM37742
cid_3244290
methyl 1-(2,1,3-benzothiadiazol-4-ylsulfonyl)cyclopropane-1-carboxylate
SMR000033162
1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-1-cyclopropanecarboxylic acid methyl ester
[ Show all ]
Inchi KeyBJRKOTLNYXDXHI-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H10N2O4S2/c1-17-10(14)11(5-6-11)19(15,16)8-4-2-3-7-9(8)13-18-12-7/h2-4H,5-6H2,1H3
PubChem CID3244290
ChEMBLCHEMBL1456551
IUPHARN/A
BindingDB37742
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<66700.0 nMN/ABindingDB
Ki<43700.0 nMN/ABindingDB
Ki<66700.0 nMPubChem BioAssay data setChEMBL

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