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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2b
Synonym	ADRA2L1 alpha2B-adrenoceptor alpha2B alpha2-C2 alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor Adra-2b adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 alpha-2B adrenergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	453
Amino acid sequence	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProt	P19328
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL266
IUPHAR	26
DrugBank	N/A

Ligand

Name	CHEMBL133579
Molecular formula	C13H16N2O
IUPAC name	6'-methoxyspiro[1,4-dihydroimidazole-5,3'-2,4-dihydro-1H-naphthalene]
Molecular weight	216.284
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	1.4
Synonyms	BDBM50031308 7''-methoxyspiro[4,5-dihydro-1H-imidazole-4,2''-(1'',2'',3'',4''-tetrahydronaphthalene)] 7-Methoxyspiro[tetralin-2,4'(5'H)-[1H]imidazole]
Inchi Key	PCMFDIVLXLOWGP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H16N2O/c1-16-12-3-2-10-4-5-13(7-11(10)6-12)8-14-9-15-13/h2-3,6,9H,4-5,7-8H2,1H3,(H,14,15)
PubChem CID	10036256
ChEMBL	CHEMBL133579
IUPHAR	N/A
BindingDB	50031308
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	99.0 nM	PMID7562941	ChEMBL
Ki	99.0 nM	PMID7562941	BindingDB

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