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GPCR

NameAlpha-2B adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra2b
SynonymADRA2L1
alpha2B-adrenoceptor
alpha2B
alpha2-C2
alpha-2BAR
[ Show all ]
DiseaseN/A for non-human GPCRs
Length453
Amino acid sequenceMSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProtP19328
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL266
IUPHAR26
DrugBankN/A

Ligand

NameCHEMBL133579
Molecular formulaC13H16N2O
IUPAC name6'-methoxyspiro[1,4-dihydroimidazole-5,3'-2,4-dihydro-1H-naphthalene]
Molecular weight216.284
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP1.4
Synonyms7''-methoxyspiro[4,5-dihydro-1H-imidazole-4,2''-(1'',2'',3'',4''-tetrahydronaphthalene)]
7-Methoxyspiro[tetralin-2,4'(5'H)-[1H]imidazole]
BDBM50031308
Inchi KeyPCMFDIVLXLOWGP-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H16N2O/c1-16-12-3-2-10-4-5-13(7-11(10)6-12)8-14-9-15-13/h2-3,6,9H,4-5,7-8H2,1H3,(H,14,15)
PubChem CID10036256
ChEMBLCHEMBL133579
IUPHARN/A
BindingDB50031308
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki99.0 nMPMID7562941ChEMBL
Ki99.0 nMPMID7562941BindingDB

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