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Name | Muscarinic acetylcholine receptor M2 |
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Species | Homo sapiens (Human) |
Gene | CHRM2 |
Synonym | cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 [ Show all ] |
Disease | Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer [ Show all ] |
Length | 466 |
Amino acid sequence | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
UniProt | P08172 |
Protein Data Bank | 5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8 |
GPCR-HGmod model | P08172 |
3D structure model | This structure is from PDB ID 5zkc. |
BioLiP | BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338 |
Therapeutic Target Database | T46185 |
ChEMBL | CHEMBL211 |
IUPHAR | 14 |
DrugBank | BE0000560 |
Name | CHEMBL199636 |
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Molecular formula | C35H50Br2N4O3 |
IUPAC name | 6-[dimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azaniumyl]hexyl-[3-(1,3-dioxobenzo[de]isoquinolin-2-yl)-2,2-dimethylpropyl]-dimethylazanium;dibromide |
Molecular weight | 734.618 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | None |
Synonyms | N/A |
Inchi Key | BKCHMSJUESXPAK-UHFFFAOYSA-L |
Inchi ID | InChI=1S/C35H50N4O3.2BrH/c1-35(2,26-37-33(41)29-18-13-16-28-17-14-19-30(32(28)29)34(37)42)27-39(5,6)25-11-8-7-10-23-38(3,4)24-12-9-21-36-22-15-20-31(36)40;;/h13-14,16-19H,7-8,10-11,15,20-27H2,1-6H3;2*1H/q+2;;/p-2 |
PubChem CID | 11535021 |
ChEMBL | CHEMBL199636 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Intrinsic activity | 0.0 - | PMID16392821 | ChEMBL |
pKb | 6.8 - | PMID16392821 | ChEMBL |
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