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Name | Nociceptin receptor |
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Species | Homo sapiens (Human) |
Gene | OPRL1 |
Synonym | Orphanin FQ receptor OP4 NOPr NOP-r NOP receptor [ Show all ] |
Disease | Inflammatory disease Major depressive disorder Central nervous system disease Heart failure Anxiety disorder [ Show all ] |
Length | 370 |
Amino acid sequence | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA |
UniProt | P41146 |
Protein Data Bank | 5dhh, 5dhg, 4ea3 |
GPCR-HGmod model | P41146 |
3D structure model | This structure is from PDB ID 5dhh. |
BioLiP | BL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294 |
Therapeutic Target Database | T52921 |
ChEMBL | CHEMBL2014 |
IUPHAR | 320 |
DrugBank | BE0002378 |
Name | CHEMBL322515 |
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Molecular formula | C27H28F3NO |
IUPAC name | 1-(3,3-diphenylpropyl)-4-[3-(trifluoromethyl)phenyl]piperidin-4-ol |
Molecular weight | 439.522 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 6.1 |
Synonyms | 1-(3,3-Diphenyl-propyl)-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol BDBM50132647 1-(3,3-Diphenylpropyl)-4-[3-(trifluoromethyl)phenyl]piperidine-4-ol |
Inchi Key | PDFCYCFNUWUGGU-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H28F3NO/c28-27(29,30)24-13-7-12-23(20-24)26(32)15-18-31(19-16-26)17-14-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,20,25,32H,14-19H2 |
PubChem CID | 11743914 |
ChEMBL | CHEMBL322515 |
IUPHAR | N/A |
BindingDB | 50132647 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | <75.0 % | PMID15454210 | ChEMBL |
Ki | 116.0 nM | PMID12951102, PMID15454210 | BindingDB,ChEMBL |
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