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GPCR

NameP2Y purinoceptor 4
SpeciesHomo sapiens (Human)
GeneP2RY4
SynonymUNR
pyrimidinoceptor
pyrimidinergic receptor P2Y
P2Y4R
P2Y4 receptor
[ Show all ]
DiseaseN/A
Length365
Amino acid sequenceMASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL
UniProtP51582
Protein Data BankN/A
GPCR-HGmod modelP51582
3D structure modelThis predicted structure model is from GPCR-EXP P51582.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2123
IUPHAR325
DrugBankN/A

Ligand

Nameuridine 5'-triphosphate
Molecular formulaC9H15N2O15P3
IUPAC name[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight484.139
Hydrogen bond acceptor15
Hydrogen bond donor7
XlogP-5.8
SynonymsKBioSS_002177
Spectrum3_001596
Uridine 5'-(tetrahydrogen triphosphate) (8CI,9CI)
Uridine, 5'-(tetrahydrogen triphosphate)
4-24-00-01222 (Beilstein Handbook Reference)
[ Show all ]
Inchi KeyPGAVKCOVUIYSFO-XVFCMESISA-N
Inchi IDInChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
PubChem CID6133
ChEMBLCHEMBL336296
IUPHAR1734
BindingDB50118213
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

ParameterValueReferenceDatabase source
EC5039.0 nMPMID17079144, PMID17011188BindingDB,ChEMBL
EC5073.0 nMPMID17302398BindingDB,ChEMBL
EC5080.0 nMPMID21528910BindingDB,ChEMBL
EC5087.0 nMPMID17125260BindingDB,ChEMBL
EC5088.0 nMPMID21417463BindingDB
EC5088.4 nMPMID21417463ChEMBL
EC5090.0 nMPMID21528910, PMID20446735, PMID18514530BindingDB,ChEMBL
EC50100.0 nMPMID11206448BindingDB,ChEMBL
EC50480.0 nMPMID22107038, PMID18760862BindingDB,ChEMBL
EC50500.0 nMPMID20095577BindingDB,ChEMBL
EC50501.187 nMPMID10779375IUPHAR
EC50900.0 nMPMID22901672BindingDB,ChEMBL
EC502500.0 nMPMID12213051BindingDB,ChEMBL

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