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Name | Alpha-2C adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA2C |
Synonym | alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I [ Show all ] |
Disease | Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease [ Show all ] |
Length | 462 |
Amino acid sequence | MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ |
UniProt | P18825 |
Protein Data Bank | N/A |
GPCR-HGmod model | P18825 |
3D structure model | This predicted structure model is from GPCR-EXP P18825. |
BioLiP | N/A |
Therapeutic Target Database | T01777 |
ChEMBL | CHEMBL1916 |
IUPHAR | 27 |
DrugBank | BE0004864, BE0000342, BE0004888 |
Name | AGN-192172 |
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Molecular formula | C12H17N5 |
IUPAC name | N-(4,5-dihydro-1H-imidazol-2-yl)-5-methyl-1,2,3,4-tetrahydroquinoxalin-6-amine |
Molecular weight | 231.303 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 4 |
XlogP | 0.7 |
Synonyms | BDBM50052881 D0L6JS Imidazolidin-2-ylidene-(5-methyl-1,2,3,4-tetrahydro-quinoxalin-6-yl)-amine CHEMBL49284 |
Inchi Key | PGOVKWAJCVAZNG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H17N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-3,13-14H,4-7H2,1H3,(H2,15,16,17) |
PubChem CID | 9816048 |
ChEMBL | CHEMBL49284 |
IUPHAR | N/A |
BindingDB | 50052881 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 120.0 nM | PMID8784451 | BindingDB,ChEMBL |
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