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GPCR

NameCannabinoid receptor 2
SpeciesRattus norvegicus (Rat)
GeneCnr2
SynonymPeripheral cannabinoid receptor
CB2-R
CB2 receptor
CB2
CB-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length360
Amino acid sequenceMAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC
UniProtQ9QZN9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2470
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2163938
Molecular formulaC27H34N2O3
IUPAC nameN-(3,5-dimethyl-1-adamantyl)-10-oxo-2-propyl-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxamide
Molecular weight434.58
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.7
SynonymsBDBM50395160
Inchi KeyBKTJKWJUVAXLAS-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H34N2O3/c1-4-6-18-13-32-21-8-5-7-19-22(21)29(18)12-20(23(19)30)24(31)28-27-11-17-9-25(2,15-27)14-26(3,10-17)16-27/h5,7-8,12,17-18H,4,6,9-11,13-16H2,1-3H3,(H,28,31)
PubChem CID71449726
ChEMBLCHEMBL2163938
IUPHARN/A
BindingDB50395160
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki10.7 nMPMID22738271BindingDB,ChEMBL

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