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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	FLUPHENAZINE
Molecular formula	C22H26F3N3OS
IUPAC name	2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
Molecular weight	437.525
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	4.4
Synonyms	NCGC00015436-04 D0P5SA 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]- NCGC00024429-04 Deconoate (TN) 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol Permitil (TN) Enanthate (TN) 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol Prestwick3_000320 Fluorfenazine pound (3/4)<4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol Prolixine (Salt/Mix) Fluphenazinum [INN-Latin] AB00053587 Sevinol KBio1_000511 Anatensol (TN) Spectrum3_001420 KBio3_002865 Biomol-NT_000023 Tox21_110146 LS-112565 C07010 Moditen (TN) CHEMBL726 1-(2-Hydroxyethyl)-4-[3-(trifluoromethyl-10-phenothiazinyl)propyl]piperazine NCGC00015436-07 Dapotum D (TN) 10-(3'-(4''-(beta-Hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine NSC62323 DSSTox_GSID_23068 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethanol Phthorphenazine Flufenazina 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazino]ethanol;hydrochloride Prolixin Fluphenazin 47646-09-3 S94 HMS2089C16 AC1L1FSB Siqualine KBio2_003337 AX8130619 Spectrum_000289 KBioSS_000769 BRD-K55127134-001-01-7 Triflumethazine MFCD00242759 CAS-146-56-5 MolPort-001-727-938 cid_6602611 D07977 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-(9CI) NCGC00015436-11 DB00623 1451-EP2298776A1 Permitil EINECS 200-702-9 2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol Prestwick1_000320 Flunanthate (TN) 4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol Prolixin Concentrate Fluphenazine [INN:BAN] A 4077 Sediten (TN) Hydrochloride, Fluphenazine Anatensol SPBio_002539 KBio2_007522 BG0198 STK050763 Lopac-F-4765 BSPBio_000320 Yespazine Moditen CHEBI:5123 NCGC00015436-02 NCGC00015436-05 Dapotum 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]- NINDS_000511 DivK1c_000511 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol # Permitil Concentrate Fludecate (TN) 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride Probes1_000254 Fluorophenazine 4-[3-(2-Trifluoromethyl-10-phenothiazyl)-propyl]-1-piperazineethanol S 94 Ftorphenazine AB00053587-18 Sevinol (TN) KBio2_000769 API0006719 Spectrum4_000828 KBioGR_001375 BPBio1_000352 Tox21_110146_1 Lyogen (TN) C22H26F3N3OS Moditen Enanthate Injection (TN) ChemDiv1_024180 0680AC 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)- NCGC00015436-08 Dapotum Injektion (TN) 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine Omca (TN) DSSTox_RID_76862 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-pipe razinyl)propyl)phenothiazine PLDUPXSUYLZYBN-UHFFFAOYSA-N Flufenazina [DCIT] Prolixin (Salt/Mix) 69-23-8 SBI-0050538.P003 HMS655L02 AJ-72569 Siqualon KBio2_004954 BCP21399 SQ 4918 KBioSS_002391 BRD-K55127134-300-05-4 UNII-S79426A41Z MLS001076508 CAS-69-23-8 MRF-0000359 cMAP_000035 D0B7SP 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)- NCGC00024429-03 Decanoate (TN) 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol Permitil (Salt/Mix) Elinol 2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol;hydrochloride Prestwick2_000320 Fluorfenazine 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-Piperazineethanol Prolixine Fluphenazinum A836405 Selecten (TN) IDI1_000511 Anatensol (Salt/Mix) Spectrum2_001199 KBio3_002320 BIDD:PXR0184 Tensofin (Salt/Mix) Lopac0_000555 BSPBio_003100 ZINC19203912 Moditen (Tabl or elixir) NCGC00015436-03 1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine NCGC00015436-06 Dapotum (TN) 10-(3'-(4"-(beta-Hydroxyethyl)-1"-piperazinyl)-propyl)-3-trifluoromethylphenothiazine NSC 62323 DSSTox_CID_3068 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol Phenothiazine, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-2-(trifluoromethyl)- Flufenazin 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;hydrochloride Probes2_000295 Fluorphenazine 4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol S79426A41Z GTPL204 AB00053587_19 Sinqualone (TN) KBio2_002386 Apo-Fluphenazine Spectrum5_001536 KBioGR_002386 BPBio1_001187 Trancin (TN) MCULE-7579992672 Calmansial Moditen Hcl cid_3372 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)- (9CI) NCGC00015436-09 1451-EP2272537A2 Pacinol DTXSID2023068 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine Prestwick0_000320 flufenazine 4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol Prolixin (TN) Fluphenazine (INN) SCHEMBL19221 HSDB 3334 AKOS001659031 SPBio_001277 KBio2_005905 BDBM78433 SR-01000003048-5 L000257 BRD-K55127134-300-07-0 Vespazine Modecate (TN) CCG-204645 NCGC00015436-01 CTK8F9822 [ Show all ]
Inchi Key	PLDUPXSUYLZYBN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
PubChem CID	3372
ChEMBL	CHEMBL726
IUPHAR	204
BindingDB	78433
DrugBank	DB00623
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	15.8489 nM	PMID7908055	IUPHAR
Ki	15.85 nM	PMID10821800	BindingDB
Ki	17.0 nM	PMID7908055	BindingDB

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