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GPCR

Name	Alpha-1D adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1D
Synonym	alpha1a/d-adrenoceptor adrenergic receptor delta1 Gpcr8 Adrd1 ADRA1R ADRA1A ADRA1 Adra-1 alpha 1D-adrenoceptor alpha 1D-adrenoreceptor alpha1D-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-adrenergic receptor 1a Alpha-1D adrenoreceptor Alpha-1D adrenoceptor Alpha-1A adrenergic receptor alpha1D-AR [ Show all ]
Disease	Urinary incontinence Benign prostatic hyperplasia Congestive heart failure Diabetes Erectile dysfunction Fecal incontinence Glaucoma Hypertension Pediatric cancer Peripheral vascular disease Prostate disease Prostate hyperplasia [ Show all ]
Length	572
Amino acid sequence	MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
UniProt	P25100
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T53381
ChEMBL	CHEMBL223
IUPHAR	24
DrugBank	BE0004863, BE0000715

Ligand

Name	FLUPHENAZINE
Molecular formula	C22H26F3N3OS
IUPAC name	2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
Molecular weight	437.525
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	4.4
Synonyms	KBio2_003337 Sevinol AX8130619 KBioSS_000769 Spectrum3_001420 BRD-K55127134-001-01-7 MFCD00242759 Tox21_110146 CAS-146-56-5 MolPort-001-727-938 cid_6602611 1-(2-Hydroxyethyl)-4-[3-(trifluoromethyl-10-phenothiazinyl)propyl]piperazine Dapotum D (TN) NCGC00015436-04 10-(3'-(4''-(beta-Hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine DSSTox_GSID_23068 NCGC00024429-04 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethanol Flufenazina Permitil (TN) 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazino]ethanol;hydrochloride Fluphenazin Prestwick3_000320 47646-09-3 HMS2089C16 Prolixine (Salt/Mix) AC1L1FSB S94 Anatensol KBio2_007522 Siqualine BG0198 Lopac-F-4765 Spectrum_000289 BSPBio_000320 Moditen Triflumethazine CHEBI:5123 D07977 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-(9CI) DB00623 NCGC00015436-07 1451-EP2298776A1 EINECS 200-702-9 NSC62323 2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol Flunanthate (TN) Phthorphenazine 4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol Fluphenazine [INN:BAN] Prolixin A 4077 Hydrochloride, Fluphenazine KBio2_000769 Sediten (TN) API0006719 KBioGR_001375 SPBio_002539 BPBio1_000352 Lyogen (TN) STK050763 C22H26F3N3OS Moditen Enanthate Injection (TN) Yespazine ChemDiv1_024180 0680AC Dapotum NCGC00015436-02 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]- DivK1c_000511 NCGC00015436-11 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol # Fludecate (TN) Permitil 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride Fluorophenazine Prestwick1_000320 4-[3-(2-Trifluoromethyl-10-phenothiazyl)-propyl]-1-piperazineethanol Ftorphenazine Prolixin Concentrate AB00053587-18 AJ-72569 KBio2_004954 Sevinol (TN) BCP21399 KBioSS_002391 Spectrum4_000828 BRD-K55127134-300-05-4 MLS001076508 Tox21_110146_1 CAS-69-23-8 cMAP_000035 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)- Dapotum Injektion (TN) NCGC00015436-05 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine DSSTox_RID_76862 NINDS_000511 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-pipe razinyl)propyl)phenothiazine Flufenazina [DCIT] Permitil Concentrate Probes1_000254 69-23-8 HMS655L02 S 94 SBI-0050538.P003 Anatensol (Salt/Mix) KBio3_002320 Siqualon BIDD:PXR0184 Lopac0_000555 SQ 4918 BSPBio_003100 Moditen (Tabl or elixir) UNII-S79426A41Z D0B7SP MRF-0000359 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)- Decanoate (TN) NCGC00015436-08 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol Elinol Omca (TN) 2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol;hydrochloride Fluorfenazine PLDUPXSUYLZYBN-UHFFFAOYSA-N 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-Piperazineethanol Fluphenazinum Prolixin (Salt/Mix) A836405 IDI1_000511 KBio2_002386 Selecten (TN) Apo-Fluphenazine KBioGR_002386 Spectrum2_001199 BPBio1_001187 MCULE-7579992672 Tensofin (Salt/Mix) Calmansial Moditen Hcl ZINC19203912 cid_3372 1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine Dapotum (TN) NCGC00015436-03 10-(3'-(4"-(beta-Hydroxyethyl)-1"-piperazinyl)-propyl)-3-trifluoromethylphenothiazine DSSTox_CID_3068 NCGC00024429-03 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol Flufenazin Permitil (Salt/Mix) 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;hydrochloride Fluorphenazine Prestwick2_000320 4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol GTPL204 Prolixine AB00053587_19 AKOS001659031 KBio2_005905 Sinqualone (TN) BDBM78433 L000257 Spectrum5_001536 BRD-K55127134-300-07-0 Modecate (TN) Trancin (TN) CCG-204645 CTK8F9822 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)- (9CI) NCGC00015436-06 1451-EP2272537A2 DTXSID2023068 NSC 62323 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine flufenazine Phenothiazine, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-2-(trifluoromethyl)- 4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol Fluphenazine (INN) Probes2_000295 HSDB 3334 S79426A41Z KBio1_000511 SCHEMBL19221 Anatensol (TN) KBio3_002865 SPBio_001277 Biomol-NT_000023 LS-112565 SR-01000003048-5 C07010 Moditen (TN) Vespazine CHEMBL726 D0P5SA NCGC00015436-01 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]- Deconoate (TN) NCGC00015436-09 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol Enanthate (TN) Pacinol 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol Fluorfenazine pound (3/4)<Prestwick0_000320 4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol Fluphenazinum [INN-Latin] Prolixin (TN) AB00053587 [ Show all ]
Inchi Key	PLDUPXSUYLZYBN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
PubChem CID	3372
ChEMBL	CHEMBL726
IUPHAR	204
BindingDB	78433
DrugBank	DB00623
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	33.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	16.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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