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GPCR

NamePutative gonadotropin-releasing hormone II receptor
SpeciesHomo sapiens (Human)
GeneGNRHR2
SynonymType II GnRH receptor
gonadotropin-releasing hormone (type 2) receptor 2, pseudogene
gonadotropin-releasing hormone (type 2) receptor 2
GnRH2 receptor
GnRH-II-R
[ Show all ]
DiseaseN/A
Length292
Amino acid sequenceMSAGNGTPWDATWNITVQWLAVDIACRTLMFLKLMATYSAAFLPVVIGLDRQAAVLNPLGSRSGVRKLLGAAWGLSFLLAFPQLFLFHTVHCAGPVPFTQCVTKGSFKAQWQETTYNLFTFCCLFLLPLTAMAICYSRIVLSVSRPQTRKGSHAPAGEFALPRSFDNCPRVRLRALRLALLILLTFILCWTPYYLLGMWYWFSPTMLTEVPPSLSHILFLLGLLNAPLDPLLYGAFTLGCRRGHQELSIDSSKEGSGRMLQEEIHAFRQLEVQKTVTSRRAGETKGISITSI
UniProtQ96P88
Protein Data BankN/A
GPCR-HGmod modelQ96P88
3D structure modelThis predicted structure model is from GPCR-EXP Q96P88.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHARN/A
DrugBankBE0000472

Ligand

Namedanazol
Molecular formulaC22H27NO2
IUPAC name(1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-ol
Molecular weight337.463
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.8
SynonymsDanoval
DTXSID2022880
(1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9-trien-17-ol
HMS3259M10
17230-88-5
[ Show all ]
Inchi KeyPOZRVZJJTULAOH-LHZXLZLDSA-N
Inchi IDInChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20+,21+,22+/m1/s1
PubChem CID28417
ChEMBLCHEMBL1479
IUPHARN/A
BindingDBN/A
DrugBankDB01406

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank

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