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GPCR

NameAlpha-2B adrenergic receptor
SpeciesDidelphis virginiana (North American opossum)
GeneADRA2B
SynonymAlpha-2B adrenoceptor
Alpha-2B adrenoreceptor
Alpha-2BAR
DiseaseN/A for non-human GPCRs
Length382
Amino acid sequenceAIAAVITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRHTWCEVYLALDVLFCTSSIVHLCAISLDRYWSVSRALEYNSKRTPRRIKGIILTVWLIAAFISLPPLIYKGDKGKKPGGRPQCKLNEEAWYILSSSIGSFFAPCLIMILVYLRIYLIAKRRNRQGPHGKQAPGDGDTGPSALGGTSTISKLPPSILPAVGEANGHSKPPGEREGGEQMGDPTSPSTPPNQSSVGPEDGSQKQEEEEEEEEEEEEECGPPAPPTSSSLQGTPNFQPSQGSQVLATLRGQVLLARGPASLGLQPWRRRTQMNREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPQHCKVPHGLF
UniProtO77715
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHARN/A
DrugBankN/A

Ligand

NameYohimbine
Molecular formulaC21H26N2O3
IUPAC namemethyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Molecular weight354.45
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.9
SynonymsYohimar
Yohimbe Extract Yohimbine
D0H4JM
Yohimex
EINECS 205-672-0
[ Show all ]
Inchi KeyBLGXFZZNTVWLAY-SCYLSFHTSA-N
Inchi IDInChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
PubChem CID8969
ChEMBLCHEMBL15245
IUPHAR102
BindingDB50203564, 50013515
DrugBankDB01392

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.04 nMPMID2894455BindingDB
Ki0.11 nMPMID7908054BindingDB
Ki0.18 nMPMID2894455BindingDB
Ki0.19 nMPMID7908054BindingDB
Ki28.0 nMPMID2894455BindingDB

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