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GPCR

NameVasopressin V2 receptor
SpeciesHomo sapiens (Human)
GeneAVPR2
SynonymAVPR V2
antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
DIR3
ADHR
[ Show all ]
DiseaseEuvolemic hyponatremia; Hypervolemic hyponatremia
Enuresis; Polyuria; Diabetes insipidus
Hypervolaemic hyponatraemia; Euvolaemic hyponatraemia
Congestive heart failure
Heart failure
[ Show all ]
Length371
Amino acid sequenceMLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
UniProtP30518
Protein Data BankN/A
GPCR-HGmod modelP30518
3D structure modelThis predicted structure model is from GPCR-EXP P30518.
BioLiPN/A
Therapeutic Target DatabaseT66237
ChEMBLCHEMBL1790
IUPHAR368
DrugBankBE0000293

Ligand

NameCHEMBL136682
Molecular formulaC21H23ClN2O2
IUPAC name(2-chloro-4-morpholin-4-ylphenyl)-(2,3,4,5-tetrahydro-1-benzazepin-1-yl)methanone
Molecular weight370.877
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.1
Synonyms1-(2-Chloro-4-morpholinobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
Inchi KeyBLLPLLSKDCAPPX-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H23ClN2O2/c22-19-15-17(23-11-13-26-14-12-23)8-9-18(19)21(25)24-10-4-3-6-16-5-1-2-7-20(16)24/h1-2,5,7-9,15H,3-4,6,10-14H2
PubChem CID10595380
ChEMBLCHEMBL136682
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
PMA8.4 %PMID11087564ChEMBL

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