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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL1762823
Molecular formulaC19H25FN6O2
IUPAC nameN-(3-fluoropropyl)-N-(2-methoxyethyl)-8-(6-methoxypyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
Molecular weight388.447
Hydrogen bond acceptor8
Hydrogen bond donor0
XlogP2.8
SynonymsBDBM50340105
N-(3-fluoropropyl)-N-(2-methoxyethyl)-8-(6-methoxypyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
Inchi KeyBLOMLVIWSNVQDS-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H25FN6O2/c1-13-17(15-6-7-16(28-4)21-12-15)18-22-14(2)23-19(26(18)24-13)25(9-5-8-20)10-11-27-3/h6-7,12H,5,8-11H2,1-4H3
PubChem CID54582098
ChEMBLCHEMBL1762823
IUPHARN/A
BindingDB50340105
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5035.0 nMPMID21411322BindingDB,ChEMBL

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