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Name | Glucagon receptor |
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Species | Homo sapiens (Human) |
Gene | GCGR |
Synonym | GL-R GGR GR glucagon receptor |
Disease | Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes [ Show all ] |
Length | 477 |
Amino acid sequence | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF |
UniProt | P47871 |
Protein Data Bank | 5yqz, 5xez, 5ee7, 5xf1 |
GPCR-HGmod model | P47871 |
3D structure model | This structure is from PDB ID 5yqz. |
BioLiP | BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437 |
Therapeutic Target Database | T60182, T87875 |
ChEMBL | CHEMBL1985 |
IUPHAR | 251 |
DrugBank | N/A |
Name | CHEMBL1922842 |
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Molecular formula | C28H24F6N8O2 |
IUPAC name | 4-[[3-methyl-4-propoxy-6-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]iminobenzimidazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamide |
Molecular weight | 618.544 |
Hydrogen bond acceptor | 12 |
Hydrogen bond donor | 2 |
XlogP | 5.6 |
Synonyms | BDBM50358376 |
Inchi Key | PUAAXTJWPWHQRM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H24F6N8O2/c1-3-11-44-22-14-19(28(32,33)34)13-21-23(22)41(2)26(35-20-6-4-5-18(12-20)27(29,30)31)42(21)15-16-7-9-17(10-8-16)24(43)36-25-37-39-40-38-25/h4-10,12-14H,3,11,15H2,1-2H3,(H2,36,37,38,39,40,43) |
PubChem CID | 57403703 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50358376 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 22.0 nM | PMID22001094 | BindingDB |
IC50 | 31.0 nM | PMID22001094 | BindingDB |
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