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GPCR

NameVasopressin V2 receptor
SpeciesHomo sapiens (Human)
GeneAVPR2
SynonymAVPR V2
antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
DIR3
ADHR
[ Show all ]
DiseaseEuvolemic hyponatremia; Hypervolemic hyponatremia
Enuresis; Polyuria; Diabetes insipidus
Hypervolaemic hyponatraemia; Euvolaemic hyponatraemia
Congestive heart failure
Heart failure
[ Show all ]
Length371
Amino acid sequenceMLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
UniProtP30518
Protein Data BankN/A
GPCR-HGmod modelP30518
3D structure modelThis predicted structure model is from GPCR-EXP P30518.
BioLiPN/A
Therapeutic Target DatabaseT66237
ChEMBLCHEMBL1790
IUPHAR368
DrugBankBE0000293

Ligand

NameCHEMBL372766
Molecular formulaC25H18F2N2O
IUPAC name[4-(3,5-difluorophenyl)phenyl]-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepin-5-yl)methanone
Molecular weight400.429
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.7
Synonyms10,11-Dihydro-10-[4-(3,5-difluorophenyl)benzoyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepine
BLTYNERWSWSLRZ-UHFFFAOYSA-N
L014909
(5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)-(3'',5''-difluoro-biphenyl-4-yl)-methanone
SCHEMBL7314707
[ Show all ]
Inchi KeyBLTYNERWSWSLRZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H18F2N2O/c26-21-12-20(13-22(27)14-21)17-7-9-18(10-8-17)25(30)29-16-23-5-3-11-28(23)15-19-4-1-2-6-24(19)29/h1-14H,15-16H2
PubChem CID22405331
ChEMBLCHEMBL372766
IUPHARN/A
BindingDB50173299
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502500.0 nMPMID16153837BindingDB,ChEMBL

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