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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesMus musculus (Mouse)
GeneNpbwr1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A for non-human GPCRs
Length329
Amino acid sequenceMHNLTLFESGGDNVSCGGSSLGCPNGSSLAPLPLPQPLAVAVPVVYGVICAVGLAGNSAVLYVLLRTPRMKTVTNVFILNLAIADELFTLVLPINIADFLLRRWPFGEVMCKLIVAVDQYNTFSSLYFLAVMSADRYLVVLATAESRRVSGRTYGAARAVSLAVWALVTLVVLPFAVFARLDEEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVTTICALYTTLLCRLRAIQLDSHAKALDRAKKRVTLLVAAILAVCLLCWTPYHLSTIVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRRSLRQLVSCRSA
UniProtP49681
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1938219
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1940528
Molecular formulaC30H34BrClN4OS
IUPAC name[(1S,2S,4R)-4-[[1-(2-bromophenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-(5-chloropyridin-2-yl)piperazin-1-yl]methanone
Molecular weight614.043
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP6.0
SynonymsBDBM50362428
Inchi KeyPVLWNYFCJZEJFC-DSNGMDLFSA-N
Inchi IDInChI=1S/C30H34BrClN4OS/c31-27-5-2-1-4-26(27)30(11-3-12-30)34-23-7-8-24(25(18-23)21-10-17-38-20-21)29(37)36-15-13-35(14-16-36)28-9-6-22(32)19-33-28/h1-2,4-6,9-10,17,19-20,23-25,34H,3,7-8,11-16,18H2/t23-,24+,25-/m1/s1
PubChem CID57403534
ChEMBLCHEMBL1940528
IUPHARN/A
BindingDB50362428
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC502196.0 nMPMID22197390BindingDB,ChEMBL
IC502208.0 nMPMID22197390BindingDB,ChEMBL

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